A super PAC with ties to Senate Majority Leader Mitch McConnellMitch McConnellTrump making calls to senators on healthcare bill Trump called Cruz to press him on ObamaCare repeal bill: report Meadows: Senate bill lacks conservative support to pass House MORE (R-Ky.) is targeting Sen. Joe ManchinJoe ManchinZinke hits Dems for delaying Interior nominees Manchin faces primary challenge from the left Sessions sequel falls flat following Comey drama MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Rodham ClintonTrump notes 'election meddling by Russia' in tweet criticizing Obama Former Obama advisor calls Fox ‘state sanctioned media’ Biden rips Senate GOP healthcare bill, says it 'isn't about healthcare' MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampHeidi HeitkampSenate Dem undecided on 2018 reelection run Trump ‘regulatory czar’: Two-for-one rule can work Congress should just say no to more green energy handouts MORE (N.D.), Claire McCaskillClaire McCaskillSenators question need for HHS cyber office Overnight Cybersecurity: Obama DHS chief defends Russian hack response | Trump huddles on grid security | Lawmakers warned about cyber threat to election systems We must protect our most vulnerable from financial fraudsters MORE (Mo.) and Joe DonnellyJoe DonnellyLawmakers sport LSU gear at baseball game in honor of Scalise Senate votes to continue arming Saudis As Yemenis suffer the consequences Overnight Defense: Mattis defends Trump budget | Senate rejects effort to block Saudi deal | Boeing to cut 50 executive jobs MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.