A super PAC with ties to Senate Majority Leader Mitch McConnellMitch McConnellTrump’s isolation grows Ellison: Trump has 'level of sympathy' for neo-Nazis, white supremacists Trump touts endorsement of second-place finisher in Alabama primary MORE (R-Ky.) is targeting Sen. Joe ManchinJoe ManchinOPINION | 5 ways Democrats can win back power in the states Trump's Democratic tax dilemma Manchin eyed as potential pick for Energy secretary: report MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Rodham ClintonAssange meets U.S. congressman, vows to prove Russia did not leak him documents High-ranking FBI official leaves Russia probe OPINION | Steve Bannon is Trump's indispensable man — don't sacrifice him to the critics MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampHeidi HeitkampTrump's Democratic tax dilemma It's time for McConnell to fight with Trump instead of against him The real litmus test is whether pro-life democrats vote for pro-life legislation MORE (N.D.), Claire McCaskillClaire McCaskillSenators push for possible FCC enforcement over Lifeline fraud Democrat senator: Trump has elevated Kim Jong-Un to the world stage It's time for McConnell to fight with Trump instead of against him MORE (Mo.) and Joe DonnellyJoe DonnellyTrump's Democratic tax dilemma FEC 'reform' a smokescreen to weaponize government against free speech It's time for McConnell to fight with Trump instead of against him MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.