A super PAC with ties to Senate Majority Leader Mitch McConnellMitch McConnellPath to 60 narrows for Trump pick Dems delay Senate panel vote on Supreme Court nominee This week: GOP picks up the pieces after healthcare defeat MORE (R-Ky.) is targeting Sen. Joe ManchinJoe ManchinCan Trump rebound after failure on healthcare bill? Path to 60 narrows for Trump pick Overnight Healthcare: Ryan visits White House amid healthcare rubble MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Rodham ClintonSchumer confronts wealthy Trump supporter in restaurant: report With GOP’s healthcare bill on ice, Dems go on offense Trump asks why Clintons' ties to Russia aren't under investigation MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampHeidi HeitkampWith GOP’s healthcare bill on ice, Dems go on offense Path to 60 narrows for Trump pick Under pressure, Dems hold back Gorsuch support MORE (N.D.), Claire McCaskillClaire McCaskillPath to 60 narrows for Trump pick Under pressure, Dems hold back Gorsuch support Overnight Defense: General warns State Department cuts would hurt military | Bergdahl lawyers appeal Trump motion | Senators demand action after nude photo scandal MORE (Mo.) and Joe DonnellyJoe DonnellyWith GOP’s healthcare bill on ice, Dems go on offense Path to 60 narrows for Trump pick The Hill’s Whip List: Where Dems stand on Trump’s Supreme Court nominee MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.