A super PAC with ties to Senate Majority Leader Mitch McConnellMitch McConnellMcConnell: Senate will pass short-term funding bill to avoid shutdown Lawmakers push one-week stopgap funding bill Overnight Finance: Inside Trump's tax plan | White House mulls order pulling out of NAFTA | New fight over Dodd-Frank begins MORE (R-Ky.) is targeting Sen. Joe ManchinJoe ManchinSenators push 'cost-effective' reg reform Congress nears deal on help for miners Senate votes to confirm Rosenstein as deputy attorney general MORE (D-W.Va.) in its first ad geared toward the 2018 midterm elections.

Manchin, a moderate Democrat, is among those up for reelection next year being targeted by Republicans, who hope to seize on President Trump's wave of support in West Virginia in the November election.

The ad, put out by the Senate Leadership Fund, splices together a slew of clips of Manchin voicing support for former Democratic presidential nominee Hillary ClintonHillary Rodham ClintonObama's speech proves hypocrisy of Democrat's anti-Wall Street rhetoric Lawmakers targeted as district politics shift Want a tremendous deal on infrastructure spending? Suspend Davis-Bacon MORE during the 2016 campaign.

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“Don’t be fooled,” a banner at the end of the ad reads, apparently casting doubt on Manchin’s willingness to work with Trump after he was elected.

Manchin has been among the Democratic senators most willing to cooperate with Trump following the bitter campaign, voting to confirm all but four of Trump’s Cabinet nominees that have gone before the Senate.

Manchin is among a handful of Senate Democrats facing potentially difficult reelection battles in red states next year. Sens. Heidi HeitkampHeidi HeitkampOvernight Regulation: Senators call for 'cost-effective' regs | FCC chief unveils plans to roll back net neutrality Senators push 'cost-effective' reg reform Battle begins over Wall Street rules MORE (N.D.), Claire McCaskillClaire McCaskillFive takeaways from the Georgia special election Picking 2018 candidates pits McConnell vs. GOP groups Potential McCaskill challenger has .7M: report MORE (Mo.) and Joe DonnellyJoe DonnellyWhat prospective college students need to know before they go — or owe Battle begins over Wall Street rules GOP rep to potential Senate rival: Don't run MORE (Ind.) are also considered vulnerable after Trump won heavily in their states.